The study of how covalent marks on DNA and histones are involved in the origin and spread of cancer cells
is also leading to new therapeutic strategies.
Much of the current hype in epigenetics stems from the recognition of its role in human cancer. Yet, intriguingly, the first epigenetic change in human tumors—global genomic DNA hypomethylation—was reported way back in the early 1980s, at about the same time the first genetic mutation in an oncogene was discovered.1 So why the delay in recognizing the importance of epigenetics in cancer?
In the 1980s epigenetics was a fledgling discipline, hampered by methodological limitations, while genetic knowledge of Continue reading
Filed under: Noticias de Salud | Tagged: Biochemistry and Molecular Biology, Biology, DNA, DNA methylation, epigenetic, Gene, Gene Expression, Histone, Lung cancer, Prader-Willi syndrome, The Scientist | 1 Comment »